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        發布時間:2015-01-23 【字號: 瀏覽次數:
                干細胞研究平臺是中國醫學科學院輸血研究所建立在相關研究成果基礎上于2011年新成立的研究中心,主要從事人多能干細胞向功能成熟造血細胞誘導分化研究和人外周血/臍血重編程為誘導性多潛能干細胞以及相關疾病模型的研究。經過多年的研究積累,已掌握了將人多能干細胞與造血Niche基質細胞共培養獲得大量造血干/祖細胞的方法,并能將人類多能干細胞來源的造血干/祖細胞誘導分化為功能成熟血細胞(紅細胞、嗜酸性粒細胞、巨噬細胞、肥大細胞等),在這些成熟誘導方法的基礎上探索全人源培養體系以及造血相關基因和小分子物質對造血分化的調控機制研究。平臺研究資源豐富,在中國首批批準建設的7家臍帶血干細胞庫之一——四川省臍帶造血干細胞庫的豐富的干細胞資源上,目前已建立高效地從少量的人外周血/臍血重編程為誘導性多能干細胞的方法。 近年來先后承擔“973”課題、國家自然科學基金面上項目等國家科研項目。分別與中國醫學科學院天津血研所、基礎醫學研究所、浙江大學等科研院所合作,并和四川新生命干細胞公司以及中科善慶醫學管理有限責任公司共建聯合實驗室從事人多能干細胞向臨床應用研究。實驗室現有科技人員16人,其中高級專業技術職稱人員2人,碩士以上學歷人員12人。近年來先后在國內外核心學術期刊發表論文26篇。平臺主要從事高效地將人多能干細胞向成熟血液細胞誘導分化研究,人外周血/臍血高效重編程為誘導性多能干細胞以及相關疾病模型的研究;探索運用全人源培養方法從人多能干細胞產生造血干祖細胞;同時探索人類早期造血相關基因以及小分子物質對造血分化的調控機制。
        The Center for Stem Cell Research & Application is a newly established one in 2011.The center mainly focus on uncovering mechanisms controlling human pluripotent stem cell (hPSCs, including hESC and hiPSCs) to differentiate into functionally mature hematopoietic cells and exploring the possibility of clinical applications. We also develop methods for efficiently reprogramming human peripheral / umbilical cord blood cells into hiPSCs. We are now fucusing on the following research:1) hPSC-derived hematopoietic stem / progenitor cells. 2)Molecular control of early human hematopoiesis by using hPSC as the model. 3) hPSC-derived erythrocytes as transfusion substitute. 4) hPSC-derived early innate immune cells and their functions. 5) Analysis of diseased hematopoiesis by using patient-specific iPSCs as the model.
        Recently, we have successfully gained various grant support from government, such as “973 Project” and National Natural Science Foundation of China, etc. We cooperate with many other institutes and universities such as State Key Lab of Experimental Hematology (Tianjin), Institute of Basic Medical Sciences, Zhejiang University, and set several joint laboratories with companies to develop possibe clinical applications. With 16 staffs, including 2 senior engineers and 12 masters and doctors, we have published more than 26 papers in recent years.
        We are interested in research on induction of hPSCs to functionally mature blood cells (erythrocytes, eosinophils, macrophages and mast cells, etc) and their possible applications. We are also interested in establishing high efficient methods to reprogram a small amount human peripheral / umbilical cord blood cells into hiPSCs and developing diseased models.We are exploring the method to induce mature blood cells in whole humanized system and uncovering mechanisms controlling early hematopoiesis through regulating genes and small molecules.


        馬 峰 
                1983年本科畢業于南京醫科大學,1992年碩士畢業于蘇州大學醫學院,2000年博士畢業于東京大學;1991-1992年,衛生部笹川獎學金研修生公派赴日(日本國信州大學)1996-1997年 衛生部笹川獎學金特別研究員公派赴日(日本國信州大學)1998-2000年 日本學術振興會博士后特別研究員(東京大學)2000-2003年 日本國東京大學醫科學研究所博士后研究員2003-2006年 日本國京都大學大學院醫學研究科助理教授。2006-2010年 日本國東京大學醫科學研究所助理教授2011-中國醫學科學院輸血研究所干細胞研究中心主任、中國醫科學院北京協和醫學院特聘教授 ,2012-中國醫學科學院輸血研究所副所長(分管科研)。長期從事造血干細胞和人類ES/iPS細胞向造血細胞誘導分化的基礎與臨床應用研究。在人類ES/iPS細胞向紅細胞以及自然免疫相關細胞等功能成熟血細胞的分化發育方面有創新成績。
        Tel:+86-28-61648510        Email:mafeng@hotmail.co.jp
        Dr. Feng Ma, Stem Cell Biologist and Pediatric Hematologist, graduated from Nanjing Medical University in 1983, he worked as a pediatrician at Zhenjiang No.1 Hospital from 1983 to 1988. Since then, he had been working at the Children’s Hospital of Suzhou University and got his Master Degree in Medical Science in 1994. He first went to Japan in 1991 for one-year research on hematopoiesis and again to Japan in 1996 (Both by Sasakawa Medical Foundation, Department of Public Health of China). He gained his PhD Degree in Medical Science at the University of Tokyo in 2000. After then, he has been serving as a Postdoctoral Research Fellow,  and then an Assistant Professor, at the Institute of Medical Science, University of Tokyo and Kyoto University.
        Dr. Ma’s recent main research is focusing on hESC / hiPSC-derived hematopoietic cells and their possible use in clinical applications. He is currently a Professor of the CAMS & PUMC and the Executive Director of the Institute of Blood Transfusion, CAMS.
        E-mail: yuzhe.yuan@gmail.com
        Yuan, Yuzhe
        2008.11, Ph. D. in science Institute of Zoology Chinese Academy of Science, China. 2008.11-present Research Associate Institute of blood transfusion Chinese Academy of Medical Sciences, China
        Research Area
        Bioinformatics Data analysis and application of deep sequencing
        This research area focus on monitoring DNA and pathogens in blood circulation, risk factors in stem cells and dried cardboard of blood, in order to get marker of cell transformation (related to cancer), and information of exogenous virus, endogenous virus, bacterial infections, mycoplasma infection and unknown emerging virions. This research work will provide basic medical theory support to transfusion medicine.
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